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Preload is related to the ventricular end-diastolic volume; a higher end-diastolic volume implies a higher preload. However, the relationship is not simple because of the restriction of the term preload to single myocytes. Preload can still be approximated by the inexpensive echocardiographic measurement end-diastolic volume or EDV.
Because greater EDVs cause greater distention of the ventricle, EDV is often used synonymously with preload, which refers to the length of the sarcomeres in cardiac muscle prior to contraction . An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected ...
An increase in sympathetic stimulation to the heart increases contractility and heart rate. An increase in contractility tends to increase stroke volume and thus a secondary increase in preload. An increase in preload results in an increased force of contraction by Starling's law of the heart; this does not require a change in contractility.
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The beginning of this article defines Preload as being both "the volume of blood present in a ventricle of the heart" and "the initial stretching of a single cardiac myocyte prior to contraction." This seems to me to be two different definitions. Can anyone with some expertise on this subject clarify this? Philfan22 07:41, 12 August 2007 (UTC)
Preload (cardiology), maximum stretch of the heart at the end of diastole; preload (software), code-prefetching software for Linux; Preload (engineering), the internal application of stress to certain mechanical systems
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