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A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
Eukaryotic cells contain organelles including mitochondria, which provide energy for cell functions; chloroplasts, which create sugars by photosynthesis, in plants; and ribosomes, which synthesise proteins. Cells were discovered by Robert Hooke in 1665, who named them after their resemblance to cells inhabited by Christian monks in a monastery.
Simplified structure of a mitochondrion. The intermembrane space (IMS) is the space occurring between or involving two or more membranes. [1] In cell biology, it is most commonly described as the region between the inner membrane and the outer membrane of a mitochondrion or a chloroplast.
In S. cerevisiae mitochondria, phosphatidylcholine makes up 38.4% of the IMM, phosphatidylethanolamine makes up 24.0%, phosphatidylinositol 16.2%, cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. [6] In the inner mitochondrial membrane, the protein-to-lipid ratio is 80:20, in contrast to the outer membrane, which is 50:50 ...
The membranes are slightly different from cell to cell and a cell's function determines the size and structure of the ER. [18] Mitochondria: Commonly known as the powerhouse of the cell is a double membrane bound cell organelle. [19] This functions for the production of energy or ATP within the cell.
[5] [6] The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation. [7] [8] There are two significant isoforms of this gene expressed in human cells, which differ slightly in structure and function. [9]
Many MC proteins preferentially catalyze the exchange of one solute for another ().A variety of these substrate carrier proteins, which are involved in energy transfer, have been found in the inner membranes of mitochondria and other eukaryotic organelles such as the peroxisome and facilitate the transport of inorganic ions, nucleotides, amino acids, keto acids and cofactors across the membrane.
The structure is known in detail only from a bacterium; [20] [21] in most organisms the complex resembles a boot with a large "ball" poking out from the membrane into the mitochondrion. [ 22 ] [ 23 ] The genes that encode the individual proteins are contained in both the cell nucleus and the mitochondrial genome , as is the case for many ...