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The UCSC Genome Browser is an online and downloadable genome browser hosted by the University of California, Santa Cruz (UCSC). [2] [3] [4] It is an interactive website offering access to genome sequence data from a variety of vertebrate and invertebrate species and major model organisms, integrated with a large collection of aligned annotations.
The Genomics Institute's scientists and engineers work on a variety of projects related to genome sequencing, computational biology, large data analytics, and data sharing. The institute also maintains a number of software tools used by researchers worldwide, including the UCSC Genome Browser, Dockstore, and the Xena Browser.
Several more genome browsers have been created, including the UCSC Genome Browser, developed in 2000 by Jim Kent and David Haussler, and the NCBI's Genome Data Viewer. [2] [3] These genome browsers may support multiple genomes, however, other genome browsers may be specific for particular species.
The three primary genome browsers—Ensembl genome browser, UCSC genome browser, and the National Centre for Biotechnology Information (NCBI)—support different sequence analysis procedures, including genome assembly, genome annotation, and comparative genomics like exploring differential expression patterns and identifying conserved regions.
The UCSC Genome Browser offers isPCR, which provides graphical as well text-file output to view PCR products on more than 100 sequenced genomes. A primer may bind to many predicted sequences, but only sequences with no or few mismatches (1 or 2, depending on location and nucleotide) at the 3' end of the primer can be used for polymerase extension.
The CCDS project tracks identical protein annotations on the reference mouse and human genomes with a stable identifier (CCDS ID), and ensures that they are consistently represented by the National Center for Biotechnology Information , Ensembl, and UCSC Genome Browser. [1]
It was created by the National Human Genome Research Institute (NHGRI) in 2008 and have become a collaborative project between the NHGRI and the European Bioinformatics Institute (EBI) since 2010. [1] As of September 2018, it has included 71,673 SNP–trait associations in 3,567 publications. [2]
After GigAssembler, Kent went on to write BLAT (BLAST-like alignment tool) [10] and the UCSC Genome Browser [11] to help analyze important genome data. Kent continues to work at UCSC primarily on web tools to help understand the human genome. He helps maintain and upgrade the browser, and has worked on comparative genomics, [12] Parasol, a job ...