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Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
They publish WebMD the Magazine, a patient-directed publication distributed bimonthly free of charge to 85 percent of physician waiting rooms. [13] Medscape is a professional portal for physicians and has training materials, a drug database, and clinical information on 30 medical specialty areas and more than 30 physician discussion boards. [ 14 ]
The medical center previously operated a main hospital in downtown Cleveland, with additional medical offices elsewhere in Cleveland as well as the suburbs of Independence, Rocky River, Solon and Westlake. [1] In 2022, the main hospital closed, although some outpatient medical services still exist at the site of the former hospital. [2]
The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout Cleveland and the wider northern Ohio region. [88] [89] Cleveland Clinic Children's Hospital also sometimes treats adults that require pediatric care. The hospital is a few blocks away from the Ronald ...
With 150 locations throughout the Cleveland metropolitan area, the University Hospitals health system encompasses hospitals, outpatient centers, and primary care clinics. University Hospitals Cleveland Medical Center is the main teaching hospital of Case Western Reserve University. [2] [3] It also has an affiliation with the Northeast Ohio ...
Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation. [1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups.
In 2006, the state had a high-tech payroll of $9.8 billion, with 155,174 high-tech employees at 10,756 high tech locations. In 2005, industry in Ohio spent $5.9 billion on research and development, with colleges spending $1.5 billion, but by 2009, $8.2 billion in R&D contracts were identified, ranking 13th nationally.
There are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 [9] and 5, [10] all caused by mutated genes. Hereditary hemochromatosis type 1 is the most frequent, and uniquely related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. [11]