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Alcoholic ketoacidosis is caused by complex physiology that is the result of prolonged and heavy alcohol intake, usually in the setting of poor nutrition. Chronic alcohol use can cause depleted hepatic glycogen stores and ethanol metabolism further impairs gluconeogenesis .
Alcoholic ketoacidosis is caused by complex physiology that is usually the result of prolonged and heavy alcohol intake in the setting of poor nutrition. Chronic alcohol use can cause depleted hepatic glycogen stores and ethanol metabolism further impairs gluconeogenesis .
Heavy alcohol consumption while in a hunger state can cause alcoholic ketoacidosis, a life-threatening metabolic derailment. The median lethal dose of alcohol in test animals is a blood alcohol content of 0.45%.
Ketoacidosis is most commonly caused by a deficiency of insulin in type 1 diabetes or late stage type 2 diabetes but can also be the result of chronic heavy alcohol use, salicylate poisoning, or isopropyl alcohol ingestion. [1] [2] Ketoacidosis causes significant metabolic derangements and is a life-threatening medical emergency. [2]
A BAC from 0.25% to 0.40% causes stupor, unconsciousness, anterograde amnesia, vomiting (death may occur due to inhalation of vomit while unconscious) and respiratory depression (potentially life-threatening). A BAC from 0.35% to 0.80% causes a coma (unconsciousness), life-threatening respiratory depression and possibly fatal alcohol poisoning.
Impact of alcohol on aging; Alcohol and cardiovascular disease; Alcohol consumption recommendations; Alcohol intolerance; Alcohol withdrawal syndrome; Alcoholic cardiomyopathy; Alcoholic hallucinosis; Alcoholic hepatitis; Alcoholic ketoacidosis; Alcoholic polyneuropathy; Aprosodia; Austrian syndrome
Signs and symptoms of alcohol withdrawal occur primarily in the central nervous system. The severity of withdrawal can vary from mild symptoms such as insomnia, trembling, and anxiety to severe and life-threatening symptoms such as alcoholic hallucinosis, delirium tremens, and autonomic instability. [9] [10]
Alcoholic ketoacidosis ... Even relatively low amounts of alcohol can be life-threatening in these cases, [222] so a strict adherence to abstinence is highly recommended.