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2. PDE5 inhibitor - Wikipedia

   en.wikipedia.org/wiki/PDE5_inhibitor

   Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

3. cGMP-specific phosphodiesterase type 5 - Wikipedia

   en.wikipedia.org/wiki/CGMP-specific...

   Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC 3.1.4.17) from the phosphodiesterase class. It is found in various tissues, most prominently the corpus cavernosum of the clitoris and of the penis as well as the retina. [5] It has also been recently discovered to play a vital role in the cardiovascular system.

4. Discovery and development of phosphodiesterase 5 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   Phosphodiesterase 5 is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder, smooth muscle and platelets. [1] It is possible to prevent cGMP hydrolysis by inhibiting PDE5 and therefore treat diseases associated with low cGMP levels, because of this, PDE5 is an ideal target for the development of ...

5. What Is the Safest ED Medication? - AOL

   www.aol.com/safest-ed-medication-105700669.html

   All four of the oral medications listed above belong to a class of drugs called PDE5 inhibitors, which work by inhibiting the effects of the enzyme phosphodiesterase type 5 (PDE5).

6. Tadalafil: Your Ultimate Guide to Dosages, Side Effects & More

   www.aol.com/tadalafil-ultimate-guide-dosages...

   Tadalafil works by inhibiting the effects of cGMP-specific phosphodiesterase type 5 (or PDE5) — an enzyme found in the smooth muscle cells of blood vessels. ... meaning it blocks ...

7. How nitric oxide supplements can enhance your sex life - AOL

   www.aol.com/nitric-oxide-supplements-enhance-sex...

   For those in need of a tried-and-true treatment for ED, the best bet may be FDA-approved oral medications known as phosphodiesterase type 5 (PDE5) inhibitors. Similar to nitric oxide, PDE5 ...