Search results
Results From The WOW.Com Content Network
Fructose 2,6-bisphosphate, abbreviated Fru-2,6-P 2, is a metabolite that allosterically affects the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis.
The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reaction . β-D-fructose 2,6-bisphosphate + H 2 O D-fructose 6-phosphate + phosphateThis enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.
Phosphofructokinase-2 (6-phosphofructo-2-kinase, PFK-2) or fructose bisphosphatase-2 (FBPase-2), is an enzyme indirectly responsible for regulating the rates of glycolysis and gluconeogenesis in cells. It catalyzes formation and degradation of a significant allosteric regulator, fructose-2,6-bisphosphate (Fru-2,6-P 2) from substrate fructose-6 ...
F-2,6-BP also binds to and decreases the activity of fructose-1,6-bisphosphatase. [9] Fructose-1,6-bisphosphatase catalyses the removal of phosphate from F-1,6-BP to form F-6-P. This reaction is part of the gluconeogenesis pathway, which synthesizes glucose, and is the reverse of glycolysis. [16] When TIGAR decreases F-2,6-BP levels ...
Researcher found that iPFK2 has a beta-hairpin N-terminal structure that secures the binding of fructose-6-phosphate to the active site via interaction with the protein's ‘2-Pase’ domain. There are two active pockets within iPFK2 for fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase which are structurally different.
The bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate, an activator of a key regulatory enzyme of glycolysis, phosphofructokinase.
This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [5]
14120 Ensembl ENSG00000130957 ENSMUSG00000021456 UniProt O00757 P70695 RefSeq (mRNA) NM_003837 NM_007994 RefSeq (protein) NP_003828 NP_032020 Location (UCSC) Chr 9: 94.56 – 94.59 Mb Chr 13: 62.98 – 63.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. Function This gene encodes a gluconeogenesis ...