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Valaciclovir, also spelled valacyclovir, is an antiviral medication used to treat outbreaks of herpes simplex or herpes zoster (shingles). [2] It is also used to prevent cytomegalovirus following a kidney transplant in high risk cases. [ 2 ]
The price of a new drug (in most cases) is limited so that the cost of therapy with the new drug is in the range of the costs of therapy with existing drugs in the same therapeutic class. The price of a breakthrough drug is limited to the median of its prices in France, Germany, Italy, Sweden, Switzerland, Britain, and the United States.
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There is little evidence to support the use of antivirals such as aciclovir and valacyclovir although they may reduce initial viral shedding. [ 57 ] [ 58 ] Antivirals are expensive, risk causing resistance to antiviral agents, and (in 1% to 10% of cases) can cause unpleasant side effects . [ 35 ]
This drives sales of the more expensive me-too drug when both drugs have virtually identical safety profiles. Similarly, Valtrex , first FDA approved in 2001 to treat persistent herpes outbreaks is a prodrug of acyclovir , first FDA approved in the mid-1980s.
Shingles, also known as herpes zoster or zona, [6] is a viral disease characterized by a painful skin rash with blisters in a localized area. [2] [7] Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. [1]
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