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The recommended dosage for suppression therapy for recurrent outbreaks is 1,000 mg of valacyclovir once a day or 400 mg Acyclovir taken twice a day. In addition to preventing outbreaks, these medications greatly reduce the chance of infecting someone while the patient is not having an outbreak. [citation needed]
In 2009, acyclovir in combination with hydrocortisone cream, marketed as Xerese, was approved in the United States for the early treatment of recurrent herpes labialis (cold sores) to reduce the likelihood of ulcerative cold sores and to shorten the lesion healing time in adults and children (six years of age and older). [61] [62]
When reactivation occurs, the virus travels down the nerves to the skin where it may cause blisters (cold sores) around the lips or mouth area. [25] In case of Herpes zoster the nose can be affected. [26] Cold sore outbreaks may be influenced by stress, menstruation, sunlight, [27] sunburn, fever, dehydration, or local skin trauma. [28]
What are cold sores? Cold sores, also known as fever blisters, can appear on your mouth or lip and are usually caused by oral herpes or herpes simplex virus type 1 (HSV-1). “It’s extremely ...
Once infected further outbreaks may occur but are generally milder. [1] The disease is typically spread by direct genital contact with the skin surface or secretions of someone who is infected. [1] This may occur during sex, including anal, oral, and manual sex. [1] [5] Sores are not required for transmission to occur. [1]
After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks. In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and may cause new sores. [8]