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Primary adrenal insufficiency predisposes to higher risk of death, mostly due to infection, cardiovascular disease, and adrenal crisis. [2] Delayed diagnosis can impair quality of life, and lack of treatment brings high mortality. [2] However, with proper diagnosis, monitoring, and treatment, people with adrenal insufficiency can live normally. [3]
Adrenal fatigue or hypoadrenia is a pseudo-scientific term used by alternative medicine providers to suggest that the adrenal glands are exhausted and unable to produce adequate quantities of hormones, primarily cortisol, due to chronic stress or infections. [1]
Adrenal gland disorders (or diseases) are conditions that interfere with the normal functioning of the adrenal glands. [1] Your body produces too much or too little of one or more hormones when you have an adrenal gland dysfunction. The type of issue you have and the degree to which it affects your body's hormone levels determine the symptoms.
With appropriate treatment, the overall outcome is generally favorable, [10] and most people are able to lead a reasonably normal life. [11] Without treatment, an adrenal crisis can result in death. [1] Addison's disease affects about 9 to 14 per 100,000 people in the developed world. [1] [3] It occurs most frequently in middle-aged females. [1]
Corticosteroid treatment has also been suggested as an early treatment option in patient with acute respiratory distress syndrome. Steroids have not been shown beneficial for sepsis alone. [ 22 ] Historically, higher doses of steroids were given, but these have been suggested to be harmful compared to the lower doses which are advocated today.
Common signs include exhaustion, reduced cognitive ability and a range of physical symptoms. The symptoms develop gradually as a result of prolonged and elevated stress, but often culminate abruptly as the disorder becomes fulminant. Recovery will generally take from six months to a full year, sometimes longer.
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