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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis .
Ondansetron was the first 5-HT 3 antagonist, developed by Glaxo around 1984. Its efficacy was first established in 1987, in animal models, [10] [11] and it was extensively studied over the following years. [12]
In 2023 the WHO highlighted a statistic: nearly half of all alcohol-attributable cancers in the WHO European Region are linked to alcohol consumption, even from "light" or "moderate" drinking – "less than 1.5 litres of wine or less than 3.5 litres of beer or less than 450 millilitres of spirits per week". [14]
There are a handful of reasons why we feel more drunk when we drink during the day.
Besides the dose ingested, factors such as the person's total body water, speed of drinking, the drink's nutritional content, and the contents of the stomach all influence the profile of blood alcohol content (BAC) over time. Breath alcohol content (BrAC) and BAC have similar profile shapes, so most forensic pharmacokinetic calculations can be ...
According to Dr. Jiseung Yoon, an addiction-medicine specialist who works with the online alcohol treatment program Monument, late-night revelers often experience symptoms of anxiety like an ...
Low doses of alcohol (one 360.0 ml (13 imp fl oz; 12 US fl oz) beer) are sleep-promoting by increasing total sleep time and reducing awakenings during the night.The sleep-promoting benefits of alcohol dissipate at moderate and higher doses of alcohol (two 12 oz. beers and three 12 oz. beers, respectively). [4]
Under conditions of moderate alcohol consumption where blood alcohol levels average 0.06–0.08 percent and decrease 0.01–0.02 percent per hour, an alcohol clearance rate of 4–5 hours would coincide with disruptions in sleep maintenance in the second half of an 8-hour sleep episode.