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More than ten thousand cases of calcium channel blocker toxicity were reported in the United States in 2010. [2] Along with beta blockers and digoxin, calcium channel blockers have one of the highest rates of death in overdose. [2] These medications first became available in the 1970s and 1980s. [2]
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists [2] are a group of medications that disrupt the movement of calcium (Ca 2+) through calcium channels. [3] Calcium channel blockers are used as antihypertensive drugs, i.e., as medications to decrease blood pressure in patients with hypertension.
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
Other causes include other forms of hypoparathyroidism, vitamin D deficiency, kidney failure, pancreatitis, calcium channel blocker overdose, rhabdomyolysis, tumor lysis syndrome, and medications such as bisphosphonates or denosumab. [1] Diagnosis should generally be confirmed by determining the corrected calcium or ionized calcium level. [2]
As a medication it is used to treat low blood sugar, beta blocker overdose, calcium channel blocker overdose, and those with anaphylaxis who do not improve with epinephrine. [10] It is given by injection into a vein, muscle, or under the skin. [10] A version given in the nose is also available. [11] Common side effects include vomiting. [10]
Baclofen marketed under the brandname of Lioresal was introduced in the United States in 1977 for the treatment of spasticity is chemically similar to phenibut but is usually not considered a gabapentinoid. Mirogabalin, under the brand name Tarlige, was approved for the treatment of neuropathic pain and postherpetic neuralgia in Japan in ...
Despite current guidelines recommending β-blockers and calcium-channel blockers as first-line therapy, there is a lack of evidence demonstrating their superiority over second-line therapies. In this comprehensive review, it is crucial to emphasize that, thus far, neither drugs nor interventions that reduce ischemia have been shown to prolong ...
Benzodiazepine overdose: 100% oxygen or hyperbaric oxygen therapy (HBOT) Carbon monoxide poisoning and cyanide poisoning: Idarucizumab: Reversal of dabigatran etexilate, an anticoagulant: Insulin + Glucagon: Beta blocker poisoning and calcium channel blocker poisoning Leucovorin: Methotrexate, trimethoprim and pyrimethamine overdose Intralipid
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