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The two mouse ROCK isoforms, ROCK1 and ROCK2, have high homology.They have 65% amino acid sequences in common and 92% homology within their kinase domains. [1] [4]ROCKs are homologous to other metazoan kinases such as myotonic dystrophy kinase (), DMPK-related cell division control protein 42 ()-binding kinases (MRCK) and citron kinase.
The ROCK1 structure is a serine/threonine kinase with molecular weight of 158 kDa. [7] It is a homodimer composed of a catalytic kinase domain (residues76-338) [11] located at the amino or N-terminus of the protein, a coiled-coil region (residues 425-1100) [11] containing the Rho-binding domain, and a pleckstrin-homology domain (residues 1118-1317) [11] with a cysteine-rich domain.
Developmental psychobiology posed this question since the lack of knowledge about the precise coordination of all cells, even those not related anatomically, in space and time during the embryonic period does not allow us to understand what forces at the cellular level coordinate four very general classes of tissue deformation, namely: tissue ...
Phosphatase and tensin homolog (PTEN) antagonises PI3K by converting PI(3,4,5)P 3 into PI(4,5)P 2. Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P 3, at the 5' position of the inositol ring. [22]
A major target of Akt kinases is glycogen synthase kinase-3. EC 2.7.11.1: Pelle: is a serine/threonine kinase that can phosphorylate itself, and also Tube and Toll. EC 2.7.11.11: Protein kinase A: consists of two domains, a small domain with several β sheet structures and a larger domain containing several α helices. The binding sites for ...
Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2.
Gneiss, a foliated metamorphic rock. Quartzite, a non-foliated metamorphic rock. Foliation in geology refers to repetitive layering in metamorphic rocks. [1] Each layer can be as thin as a sheet of paper, or over a meter in thickness. [1] The word comes from the Latin folium, meaning "leaf", and refers to the sheet-like planar structure. [1]
Conglomerate (/ k ən ˈ ɡ l ɒ m ər ɪ t /) is a sedimentary rock made up of rounded gravel-sized pieces of rock surrounded by finer-grained sediments (such as sand, silt, or clay). The larger fragments within conglomerate are called clasts, while the finer sediment surrounding the clasts is called the matrix.