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The hunting reaction or hunting response is a process of alternating vasoconstriction and vasodilation in extremities exposed to cold. The term Lewis reaction is used too, named after Thomas Lewis, who first described the effect in 1930. [1] Vasoconstriction occurs first to reduce heat loss, but also results in strong cooling of the extremities.
The tenth (X) cranial nerve, (the vagus nerve) – part of the autonomic nervous system – then produces bradycardia and other neural pathways elicit peripheral vasoconstriction, restricting blood from limbs and all organs to preserve blood and oxygen for the heart and the brain (and lungs), concentrating flow in a heart–brain circuit and ...
Vascular resistance is the resistance that must be overcome for blood to flow through the circulatory system.The resistance offered by the systemic circulation is known as the systemic vascular resistance or may sometimes be called by another term total peripheral resistance, while the resistance caused by the pulmonary circulation is known as the pulmonary vascular resistance.
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation , the widening of blood vessels.
PGD 2 promotes bronchoconstriction and vasoconstriction during times of Inflammation to alert the host of danger. Its concentration in asthma patients is 10 times higher than in control patients, especially after it is brought into contact with allergens , air pollution , secondhand smoke and smoke .
Experiments have shown that three other vascular responses to immersion of the finger in cold water are possible: a continuous state of vasoconstriction; slow, steady, and continuous rewarming; and a proportional control form in which the blood vessel diameter remains constant after an initial phase of vasoconstriction.
Many of the genes repressed during cold shock are involved in cell metabolism. By knowing the mechanism by which these genes respond, one can potentially tune it, in genetically modified bacteria, to modify at which temperature is the response to cold shock activated. This modification could reduce the energy costs of bioreactors. [11]
Alpha 1 blockers inhibit vasoconstriction normally initiated by the baroreceptor reflex upon postural change and the subsequent drop in pressure. [26] Other antihypertensive medications may also cause orthostatic hypotension, in addition to anticholinergics , dopaminergic drugs, opiates and psychoactive medications .