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Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter and many micrometers in length. [ 1 ] Together with microtubules (~25 nm) and microfilaments (7 nm), they form the neuronal cytoskeleton .
There are four major neurofilament subunits, NF-L, NF-M, NF-H and α-internexin. These form heteropolymers which assemble to produce 10 nm neurofilaments which are only expressed in neurons where they are major structural proteins, particularly concentrated in large projection axons.
Neurofilaments are type IV intermediate filament heteropolymers composed of light , medium (this protein), and heavy chains. Neurofilaments comprise the exoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein.
Neurofilaments – the type IV family of intermediate filaments that is found in high concentrations along the axons of vertebrate neurons.
Neurotubules are microtubules found in neurons in nervous tissues. [1] Along with neurofilaments and microfilaments, they form the cytoskeleton of neurons. Neurotubules are undivided hollow cylinders that are made up of tubulin protein polymers [2] and arrays parallel to the plasma membrane in neurons. [3]
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Type 4 intermediate filaments are the neurofilaments found in neurons. They can be found in many different motor axons supporting these cells. Type 5 intermediate filaments are composed of nuclear lamins which can be found in the nuclear envelope of many eukaryotic cells.
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