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However, these cells did not self-renew and were subsequently depleted as they generated new neurons, thus failing to satisfy the requirement for stem cells. [6] [7] One study observed that ependymal cells from the lining of the lateral ventricle might be a source for cells which can be transplanted into the cochlea to reverse hearing loss. [8]
This schematic illustrates the four different types of glial cells, all of which possess cytoplasmic processes: ependymal cells (light pink), astrocytes (green), microglia (red), and oligodendrocytes (light blue). Cell bodies of neurons are in yellow (Their axons are surrounded by myelin, produced by oligodendrocytes).
As the cells grow, the neurite tangle remains centrally located and the cell bodies are squeezed to the periphery, thus explaining the rosette pattern. Depending upon their location, ependymal cells may display 2 cell poles. A luminal pole projects to the ependymal lining of a ventricle and a "submesenchymal pole" projects toward the surface of ...
Ependymal cells: Ependymal cells, also named ependymocytes, line the spinal cord and the ventricular system of the brain. These cells are involved in the creation and secretion of cerebrospinal fluid (CSF) and beat their cilia to help circulate the CSF and make up the blood-CSF barrier. They are also thought to act as neural stem cells. [15] CNS
Ependymal cells secrete high molecular mass glycoproteins into the cerebrospinal fluid, in which the bulk of them condense to form a filamentous structure named Reissner's fiber. [4] The subcommissural organ/ Reissner's fiber complex is thought to be involved in the reabsorption and circulation of the cerebrospinal fluid, and with functions ...
The central canal (also known as spinal foramen or ependymal canal) is the cerebrospinal fluid-filled space that runs through the spinal cord. [1] The central canal lies below and is connected to the ventricular system of the brain , from which it receives cerebrospinal fluid, and shares the same ependymal lining.
Tanycytes are highly specialized ependymal cells found in the third ventricle of the brain, and on the floor of the fourth ventricle. Each tanycyte has a long basal process that extends deep into the hypothalamus. It is possible that their function is to transfer chemical signals from the cerebrospinal fluid to the central nervous system.
The subependymal zone (SEZ) is a cell layer below the ependyma in the lateral ventricles of the brain. It is an adult version of the embryonic forebrain germinal zone.This region contains adult neural stem cells also called neuroepithelial cells which have the potential to generate new neurons and glial cells. [1]