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Images of CAA collected at 1.5 T. Left, conventional T2* (TE=20 ms), center, SWI processed magnitude image (TE=40 ms) and right, SWI phase image (TE=40 ms) Gradient recalled echo (GRE) imaging is the conventional way to detect hemorrhage in CAA , however SWI is a much more sensitive technique that can reveal many micro-hemorrhages that are ...
Cerebral microhemorrhages is a smaller form of hemorrhagic parenchymal contusion and are typically found in white matter. Such microhemorrhages are difficult to be detected on CT scan, but easily detected on gradient echo and susceptibility weighted imaging on MRI scan as hypointense susceptibility blooming.
CAA is associated with brain hemorrhages, particularly microhemorrhages.The accumulation of amyloid beta peptide deposits in the blood vessel walls results in damage of the blood vessels and hindrance of normal blood flow, making blood vessels more prone to bleeding [10] Since CAA can be caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds [11] are more ...
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For spontaneous intracerebral hemorrhage seen on CT scan, the death rate is 34–50% by 30 days after the injury, [22] and half of the deaths occur in the first 2 days. [51] Even though the majority of deaths occur in the first few days after ICH, survivors have a long-term excess mortality rate of 27% compared to the general population. [ 52 ]
On the other hand, modeling diffusion in tissues is becoming very complex. Among most popular models are the biexponential model, which assumes the presence of 2 water pools in slow or intermediate exchange [17] [18] and the cumulant-expansion (also called Kurtosis) model, [19] [20] [21] which does not necessarily require the presence of 2 pools.
T 2 *-weighted GRE sequences can detect microhemorrhages as seen in most vestibular schwannomas, thereby differentiating them from meningiomas. [ 2 ] The T 2 *-weighted GRE sequence can detect a "middle cerebral artery susceptibility sign", which is a dark linear filling defect that is wider than the corresponding artery on the contralateral side.
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