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Figure 1. TATA box structural elements. The TATA box consensus sequence is TATAWAW, where W is either A or T. In molecular biology, the TATA box (also called the Goldberg–Hogness box) [1] is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes. [2]
The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters .
TATA-box binding protein like 2 is a protein that in humans is encoded by the TBPL2 gene. [5] The TBPL2 protein is also known as TBP-related factor 3 (TRF3) and TATA binding protein 2 (TBP2). The protein was independently discovered in three laboratories as a vertebrate-specific family member of TATA-binding protein (TBP).
The archaeal promoter resembles an eukaryotic one: a TATA box (at -26/-27) and an upstream BRE (at -33/-34) are commonly found, binding to TBP and TFB (homolog of TFIIB). [3] There are also occasionally an initiator element (INR) near the transcription start site [TSS], and a promoter proximal element (PPE) between BRE-TATA and TSS.
A common basal promoter is the TATAAAAAA sequence known as the TATA box. The TATA box is a complex with several different proteins including transcription factor II D (TFIID) which includes the TATA-binding protein (TBP) that binds to the TATA box along with 13 other proteins that bind to TBP. The TATA box binding proteins also include the ...
However, Gilbert syndrome can arise without TATA box promoter polymorphic variants; in some populations, particularly healthy Southeast and East Asians, Gilbert's syndrome is more often a consequence of heterozygote missense mutations (such as Gly71Arg also known as UGT1A1*6, Tyr486Asp also known as UGT1A1*7, Pro364Leu also known as UGT1A1*73 ...
T-box transcription factor TBX5, (T-box protein 5) is a protein that in humans is encoded by the TBX5 gene. [ 5 ] [ 6 ] [ 7 ] Abnormalities in the TBX5 gene can result in altered limb development, Holt-Oram syndrome , Tetra-amelia syndrome , and cardiac and skeletal problems.
237336 Ensembl ENSG00000028839 ENSMUSG00000071359 UniProt P62380 Q7Z6T9 P62340 RefSeq (mRNA) NM_004865 NM_001253676 NM_011603 RefSeq (protein) NP_001240605 NP_004856 NP_035733 Location (UCSC) Chr 6: 133.95 – 133.99 Mb Chr 10: 22.58 – 22.61 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 ...