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Bullous pemphigoid (a type of pemphigoid) is an autoimmune pruritic skin disease that typically occurs in people aged over 60, that may involve the formation of ...
Before the advent of modern treatments, mortality for the disease was close to 90%. Today, the mortality rate with treatment is in the range of 5% to 15%, after the introduction of corticosteroids as primary treatment. [3] Nevertheless, in 1998, pemphigus vulgaris was the fourth most common cause of death due to a skin disorder.
The factors that determine the type of therapy used for mucous membrane pemphigoid are: [1] site(s) of involvement, [2] severity of disease, [3] rate of progression. Oral mucosa is the most common site being affected in mucous membrane pemphigoid.
Bullous pemphigoid, pemphigus vulgaris, friction blisters, insect bites [5] Treatment: Wound care, pain control, controlling infections, nutritional support [2] Prognosis: Death usually occurs during early adulthood: Frequency: around 1 in 500,000 [5]
The skin sample needs to be obtained from an unaffected area adjacent to a lesion. Testing in more detail follows depending on the results from the DIF. Prompt diagnosis of PNP is crucial due to the high mortality rate of the disease. [4] Camisa and Helm revised the original criteria from Anhalt et al. [5] into major and minor signs indicating ...
Mucous membrane pemphigoid is a rare chronic autoimmune subepithelial blistering disease characterized by erosive lesions of the mucous membranes and skin. [3] It is one of the pemphigoid diseases that can result in scarring.
Intraorally, it resembles the more common diseases lichen planus and mucous membrane pemphigoid. [13] Definitive diagnosis requires examination of a skin or mucous membrane biopsy by a dermatopathologist or oral pathologist. The skin biopsy is taken from the edge of a blister, prepared for histopathology and examined with a microscope.
Bullous pemphigoid: IgG, IgE [1] NC16A terminal of BPAG2 BPAG1: 180 230 Gestational pemphigoid: IgG1: NC16A terminal of BPAG2 BPAG1: 180 230 Cicatricial pemphigoid: C-terminal of BPAG2: 180 Ocular cicatricial pemphigoid: Integrin beta-4 subunit: 200 Antiepiligrin cicatricial pemphigoid [nb 1] Laminin 5 (Epiligrin, Laminin 332) Linear IgA ...