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Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in humans that is encoded by the SLC5A1 gene [4] [5] which encodes the production of the SGLT1 protein to line the absorptive cells in the small intestine and the epithelial cells of the kidney tubules of the nephron for the purpose of glucose uptake into cells. [6]
SLC5A4, also known as SGLT3, is a member of the sodium-glucose cotransporter family. Unlike SGLT1 and SGLT2, which are efficient glucose transporters, SGLT3 functions primarily as a glucose sensor rather than a transporter. It has a low affinity for glucose and does not significantly contribute to glucose transport across cell membranes.
Na + /glucose cotransporter (SGLT1) – is also known as sodium-glucose cotransporter 1 and is encoded by the SLC5A1 gene. SGLT1 is an electrogenic transporter as the sodium electrochemical gradient drives glucose uphill into the cells.
When asked how sotagliflozin might help lower heart attack and stroke risk, Bhatt said it may be because the drug also blocks the SGLT1 (sodium-glucose cotransporter 1) receptor as well.
[1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC ) and is the basis for the official HGNC names of the genes that encode these transporters.
GLP-1 agonist drugs like Ozempic, ... (GLP-1 agonists) — which include medications like Ozempic and Wegovy — and sodium glucose cotransporter 2 (SGLT2) ...
high/intermediate-affinity glucose transporter; induced by low glucose level [3] Hxt3: Vm = 18.5, Kd = 0.078, Km = 28.6/34.2 [1] - 60 mM [3] low-affinity glucose transporter [3] Hxt4: Vm = 12.0, Kd = 0.049, Km = 6.2 [1] intermediate-affinity glucose transporter [3] Hxt5: Km = 10 mM [4] Moderate glucose affinity. Abundant during stationary phase ...
Other diabetes drugs, specifically sodium-glucose cotransporter 2 (SGLT2) inhibitors, can also lead to a reduction in lean mass. This includes canagliflozin (Invokana®) and dapagliflozin (Farxiga®).