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Gas gangreneX (also known as clostridial myonecrosis [1]) is a bacterial infection that produces tissue gas in gangrene. This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. About 1,000 cases of gas gangrene are reported yearly in the United States. [2] Myonecrosis is a condition of necrotic damage, specific to ...
Gangrene itself happens when the tissue loses blood flow and becomes deprived of oxygen and nutrients. Without proper blood supply, cells in the affected area start dying, leading to decay. There are different types of gangrene, including dry, wet, and gas gangrene, depending on the underlying cause and the conditions of the tissue.
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Clostridium perfringens is the most common bacterial agent for gas gangrene. [45] Gas gangrene is induced by α-toxin that embeds itself into the plasma membrane of cells and disrupts normal cellular function by altering membrane structure. [8] Some symptoms include blisters, tachycardia, swelling, and jaundice. [45]
Humans may also carry the GAS either on the skin or in the throat and show no symptoms. [8] These carriers are less contagious than symptomatic carriers of the bacteria. [8] The non-invasive infections caused by GAS tend to be less severe and more common. They occur when the bacteria colonizes the throat area, where it recognizes epithelial ...
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
She is also known for preparing, during 1935–1936, the standard for gas gangrene toxins and anti-toxins. [11] One of Bengtson's other research interests was typhus , an exceedingly dangerous interest and she, like many other typhus researchers, eventually contracted the disease, although she recovered fully. [ 11 ]
Gas gangrene due to diabetes: Symptoms: Pus from a wound, redness, swelling, pain, warmth [1] Complications: Infection of the bone, tissue death, sepsis, amputation [2] Causes: Diabetic foot ulcer [2] Diagnostic method: Based on symptoms [1] Differential diagnosis: Phlegmasia cerulea dolens, ischemic limb [2] Prevention: Appropriate shoes [2 ...