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The risk of liver damage appears to be only for patients already at risk, unlike the antidepressant nefazodone, which, though rare, can spontaneously cause liver failure in healthy patients. [13] Duloxetine is also approved for major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic neuropathy, chronic musculoskeletal pain ...
Duloxetine, tricyclic antidepressants, and anticonvulsants have similar tolerability while opioids cause more side effects. [34] Another review in Prescrire International considered the moderate pain relief achieved with duloxetine to be clinically insignificant and the results of the clinical trials unconvincing.
Duloxetine is also FDA-approved to help treat other conditions, including chronic musculoskeletal pain, generalized anxiety disorder (GAD), diabetes-related neuropathy pain and fibromyalgia.
Antidepressants can cause various adverse effects, depending on the individual and the drug in question. [ 123 ] Almost any medication involved with serotonin regulation has the potential to cause serotonin toxicity (also known as serotonin syndrome ) – an excess of serotonin that can induce mania, restlessness, agitation, emotional lability ...
The Food and Drug Administration has announced a recall for thousands of bottles of the antidepressant duloxetine, sold under brand names like Cymbalta, due to the presence of a chemical that can ...
Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as erectile dysfunction ...
Cross-reactivity, in a general sense, is the reactivity of an observed agent which initiates reactions outside the main reaction expected.This has implications for any kind of test or assay, including diagnostic tests in medicine, and can be a cause of false positives.
Over 7,100 bottles of Duloxetine were recalled, including 500 delayed-release 20mg capsules. The lot number is 220128, and the expiration date is 12/2024, per the FDA report.