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Together with Alexander Rudensky, Janeway also characterized how self antigens associate with MHC class II molecules. [6] Janeway is particularly well known as the lead author of Immunobiology, a standard textbook on immunology. Since the 2008 publishing of its seventh edition, it has been renamed as Janeway's Immunobiology in his memory. [7]
Charles Janeway (1943-2003), wrote the standard textbook Immunobiology; Dermot Kelleher; Tadamitsu Kishimoto (1939-) Jan Klein (1936-), Mhc; Mary Loveless (1899-1991), insect venom allergy; Tak Wah Mak (1946-), discovery of the T-cell receptor; Alberto Mantovani; Polly Matzinger (1947-), immunological tolerance, Danger Model, Hyppo Model; Ira ...
In his subsequent studies in Janeway laboratory at Yale University, he provided the first evidence that components from a diverse origin of microbes, which was called pathogen-associated molecular patterns by Janeway, induce co-stimulatory activity in antigen-presenting cells, and proposed that microbial induction of co-stimulatory molecules ...
The 8th edition of Janeway's Immunobiology defines tolerance as "immunologically unresponsive...to another's tissues.". [2] Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents.
The following outline is provided as an overview of and topical guide to immunology: . Immunology – study of all aspects of the immune system in all organisms. [1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency ...
The clonal selection theory can be summarised with the following four tenets: Each lymphocyte bears a single type of receptor with a unique specificity (generated by V(D)J recombination).
In 1997, Charles Janeway and Ruslan Medzhitov showed that a toll-like receptor now known as TLR4 could, when artificially ligated using antibodies, induce the activation of certain genes necessary for initiating an adaptive immune response. [7] TLR 4 function as an LPS sensing receptor was discovered by Bruce A. Beutler and colleagues. [73]
T-cell dependent B-cell activation, showing TH2-cell (left) B-cell (right) and several interaction molecules self-made according to Janeway et al, Immunologie (Berlin, 2002) Following development in the thymus, these cells (termed recent thymic emigrants (RTE)) egress from the thymus and home to secondary lymphoid organs (SLO; spleen and lymph ...