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Emollient laxatives, also known as stool softeners, are anionic surfactants that enable additional water and fats to be incorporated in the stool, making movement through the bowels easier. Properties. Site of action: small and large intestines; Onset of action: 12–72 hours; Examples: Docusate (Colace, Diocto), Gibs-Eze [3]
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Bristol stool scale. Constipation is a symptom, not a disease. Most commonly, constipation is thought of as infrequent bowel movements, usually fewer than 3 stools per week. [15] [16] However, people may have other complaints as well including: [3] [17] Straining with bowel movements; Excessive time needed to pass a bowel movement; Hard stools
Dantron is a stimulant drug and stool softener [31] used alone or in combinations in enemas. [32] Considered to be a carcinogen [33] its use is limited, e.g., restricted in the UK to patients who already have a diagnosis of terminal cancer and not used at all in the USA. Docusate [34] [35]
Sodium picosulfate is a prodrug. [5] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridyl)methane (DPM, BHPM).
Using stool-softening agents; Scheduled sitting times, typically after meals; The initial clean-out is achieved with enemas, laxatives, or both. The predominant approach today is the use of oral stool softeners like Movicol, Miralax, lactulose, mineral oil, etc. Following that, enemas and laxatives are used daily to keep the stools soft and ...