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A steady-state plasma level of dofetilide is achieved in 2–3 days. 80% of dofetilide is excreted by the kidneys, so the dose of dofetilide should be adjusted in individuals with chronic kidney disease, based on creatinine clearance. In the kidneys, dofetilide is eliminated via cation exchange (secretion).
Mexiletine (sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea.
One common off-label use for topiramate is in the treatment of bipolar disorder. [ 25 ] [ 26 ] [ 27 ] A review published in 2010 suggested a benefit of topiramate in the treatment of symptoms of borderline personality disorder , however the authors noted that this was based only on one randomized controlled trial and requires replication.
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Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
Ozempic has taken the world by storm – largely due to the medication's weight loss effect and rumored use by celebrities and the wealthy.. But some physicians want to shift this narrative ...
When ants bite humans, it grabs the skin and also sprays a compound called formic acid, Frye explains. Ant bites tend to be small, swollen bumps that appear in clusters, Kassouf says.
Barbital, then called "Veronal", was first synthesized in 1902 by German chemists Emil Fischer and Joseph von Mering, who published their discovery in 1903. [2] Barbital was prepared by condensing diethylmalonic ester with urea in the presence of sodium ethoxide, or by adding at least two molar equivalents of ethyl iodide to the silver salt of malonylurea (barbituric acid) or possibly to a ...