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Isosorbide dinitrate is in the nitrate family of medications and works by dilating blood vessels. [1] Isosorbide dinitrate was first written about in 1939. [3] It is on the World Health Organization's List of Essential Medicines. [4] Isosorbide dinitrate is available as a generic medication. [1] [5] A long-acting form exists. [1]
The first long-acting (depot) injections were antipsychotics fluphenazine and haloperidol. [2] The concept of a depot injection arose before 1950, and originally was used to describe antibiotic injections that lasted longer to allow for less frequent administration.
A common nitrate test, known as the brown ring test [2] can be performed by adding iron(II) sulfate to a solution of a nitrate, then slowly adding concentrated sulfuric acid such that the acid forms a layer below the aqueous solution. A brown ring will form at the junction of the two layers, indicating the presence of the nitrate ion. [3]
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).
Gallium nitrate (brand name Ganite) is the gallium salt of nitric acid with the chemical formula Ga(NO 3) 3. It is a drug used to treat symptomatic hypercalcemia secondary to cancer. It works by preventing the breakdown of bone through the inhibition of osteoclast activity, thus lowering the amount of free calcium in the blood.
Ingesting too much nitrite and/or nitrate through well water is suspected to cause methemoglobinemia. [17] 95% of the nitrite ingested in modern diets comes from bacterial conversion of nitrates naturally found in vegetables. [18] However, potentially cancer-causing nitroso compounds are not made in the pH-neutral colon.
When heated to 150–180 °C, it decomposes with autooxidation to plutonium (VI) with the formation of plutonyl nitrate (PuO 2 (NO 3) 2).Upon evaporation of concentrated nitric acid solutions of plutonium nitrate and alkali metal nitrates, double nitrates of the composition Me 2 [Pu(NO 3) 6] are formed, where Me = Cs +, Rb +, K +, Tl +, NH 4 +, analogous to ceric ammonium nitrate.
Rhodium(III) nitrate is a inorganic compound, a salt of rhodium and nitric acid with the formula Rh(NO 3) 3. This anhydrous complex has been the subject of theoretical analysis but has not been isolated. [ 4 ]