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  2. PI-RADS - Wikipedia

    en.wikipedia.org/wiki/PI-RADS

    In a 2015 articles in the Journal of Urology, Thompson reported multi-parametric MRI detection of significant prostate cancer had sensitivity of 96%, specificity of 36%, negative predictive value and positive predictive values of 92% and 52%; when PI-RADS was incorporated into a multivariate analysis (PSA, digital rectal exam, prostate volume ...

  3. Gleason grading system - Wikipedia

    en.wikipedia.org/wiki/Gleason_grading_system

    The cancer is typically located in the peripheral zone usually the posterior portion, explaining the rationale of performing the digital rectal exam. [ citation needed ] Tumors with Gleason scores 8-10 tend to be advanced neoplasms that are unlikely to be cured.

  4. Prostate - Wikipedia

    en.wikipedia.org/wiki/Prostate

    [2] ~10–20% of prostate cancers originate in this zone. It is the region of the prostate gland that grows throughout life and causes the disease of benign prostatic enlargement. [6] [7] Anterior fibro-muscular zone (or stroma) —

  5. Benign prostatic hyperplasia - Wikipedia

    en.wikipedia.org/wiki/Benign_prostatic_hyperplasia

    [47]: 694 In BPH, the majority of growth occurs in the transition zone (TZ) of the prostate. [47]: 694 In addition to these two classic areas, the peripheral zone (PZ) is also involved to a lesser extent. [47]: 695 Prostatic cancer typically occurs in the PZ. However, BPH nodules, usually from the TZ are often biopsied anyway to rule out cancer ...

  6. High-grade prostatic intraepithelial neoplasia - Wikipedia

    en.wikipedia.org/wiki/High-grade_prostatic...

    There are several reasons why PIN is the most likely prostate cancer precursor. [3] PIN is more common in men with prostate cancer. High grade PIN can be found in 85 to 100% of radical prostatectomy specimens, [4] nearby or even in connection with prostate cancer. It tends to occur in the peripheral zone of the prostate.

  7. Prostate cancer - Wikipedia

    en.wikipedia.org/wiki/Prostate_cancer

    MRI results can help distinguish those who have potentially dangerous tumors from those who do not. [26] A definitive diagnosis of prostate cancer requires a biopsy of the prostate. Prostate biopsies are typically taken by a needle passing through the rectum or perineum, guided by transrectal ultrasonography, MRI, or a combination of the two.