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The mesothelium is a membrane composed of simple squamous epithelial cells of mesodermal origin, [2] which forms the lining of several body cavities: the pleura (pleural cavity around the lungs), peritoneum (abdominopelvic cavity including the mesentery, omenta, falciform ligament and the perimetrium) and pericardium (around the heart).
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs (known as the mesothelium). [10] The area most commonly affected is the lining of the lungs and chest wall.
A serous membrane is an epithelial membrane composed of mesodermally derived epithelium called the mesothelium that is supported by connective tissue. [2] These membranes line the coelomic cavities of the body, that is, those cavities that do not open to the outside, and they cover the organs located within those cavities.
The triggering injury may affect the superficial mesothelial cells directly or indirectly and may be inflammatory, infectious, or neoplastic in nature. Mesothelial hyperplasia is frequently seen in the following conditions: ovarian neoplasms (benign or malignant), peritoneal effusion from cardiac, renal, or hepatic insufficiency, and inflammatory pelvic disease with tubo-ovarian abscess.
The mesoderm forms mesenchyme, mesothelium and coelomocytes. Mesothelium lines coeloms . Mesoderm forms the muscles in a process known as myogenesis , septa (cross-wise partitions) and mesenteries (length-wise partitions); and forms part of the gonads (the rest being the gametes ).
Mesothelin is a 40 kDa protein that is expressed in mesothelial cells. [7] The protein was first identified by its reactivity with monoclonal antibody K1. [8] Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named ...
Peritoneal mesothelioma is the name given to the cancer that attacks the lining of the abdomen.This type of cancer affects the lining that protects the contents of the abdomen and which also provides a lubricating fluid to enable the organs to move and work properly.
Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath.. The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (simple squamous epithelium) which produce the lubricating serous fluid.