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Proliferating supporting cells can acquire hair cell fate in mitotic division. The mouse's neonatal supporting cells proliferate after hair cell death and regenerate hair cells after damage. [26] The neonatal cochlea is resistant to hair cell damage caused by exposure to noise or drugs, which are toxic to the cochlea, or auditory nerve, in vivo ...
The supporting cells are differentiated from the hair cells, when early embryonic hair cells express ligands that bind to the Notch receptors would prevent them from obtaining the hair cell phenotype, and these cells would differentiate into supporting cells, this is one of the reasons that the supporting cells are able to regenerate new hair ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
In vivo, oncomodulin promotes regeneration of the optic nerve in rats. [5] It has also been found in different types of human and rodent tumors. [3] However, it has never been found in healthy human or rat tissues. [3] To date, it has been found in the central nervous system in inner ear hair cells and
The DRF funded research led, in 1987, to the discovery of spontaneous regeneration of hair cells in chickens, thus igniting the field of hair cell regeneration in humans. Research on the regrowth of cochlea cells may lead to medical treatments that restore hearing.
In the semicircular canals, the hair cells are found in the crista ampullaris, and the stereocilia protrude into the ampullary cupula. Here, the stereocilia are all oriented in the same direction. In the otoliths, the hair cells are topped by small, calcium carbonate crystals called otoconia. Unlike the semicircular ducts, the kinocilia of hair ...
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Rubel and colleagues demonstrated that hair cell regeneration occurred in birds after exposure to aminoglycoside antibiotics [14] or acoustic trauma, [15] paralleling studies by Cotanche [16] and Corwin and Cotanche. [17] Prior to these studies it was generally believed that hair cell regeneration did not occur in warm-blooded animals. [18]
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