Search results
Results From The WOW.Com Content Network
The inner nuclear membrane encloses the nucleoplasm, and is covered by the nuclear lamina, a mesh of intermediate filaments which stabilizes the nuclear membrane as well as being involved in chromatin function. [9] It is connected to the outer membrane by nuclear pores which penetrate the membranes.
Inner nuclear membrane proteins (INM proteins) are membrane proteins that are embedded in or associated with the inner membrane of the nuclear envelope. There are about 60 INM proteins, most of which are poorly characterized with respect to structure and function. [ 2 ]
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins. The SUN-domain proteins are membrane-embedded proteins within the inner nuclear membrane (INM).
Structure and function of the nuclear lamina. The nuclear lamina lies on the inner surface of the inner nuclear membrane (INM), where it serves to maintain nuclear stability, organize chromatin and bind nuclear pore complexes (NPCs) and a steadily growing list of nuclear envelope proteins (purple) and transcription factors (pink). Nuclear ...
The outer nuclear membrane is continuous with the rough endoplasmic reticulum membrane, and like that structure, features ribosomes attached to the surface. The outer membrane is also continuous with the inner nuclear membrane since the two layers are fused together at numerous tiny holes called nuclear pores that perforate the nuclear envelope.
The inner membrane surrounds the nuclear content, providing its defining edge. [11]: 14 Embedded within the inner membrane, various proteins bind the intermediate filaments that give the nucleus its structure. [10]: 649 The outer membrane encloses the inner membrane, and is continuous with the adjacent endoplasmic reticulum membrane.
Lamins, also known as nuclear lamins are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope .
Emerin, together with LEMD3, is a LEM domain-containing integral protein of the inner nuclear membrane in vertebrates. Emerin is highly expressed in cardiac and skeletal muscle . In cardiac muscle , emerin localizes to adherens junctions within intercalated discs where it appears to function in mechanotransduction of cellular strain and in beta ...