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ME/CFS causes debilitating fatigue, sleep problems, and post-exertional malaise (PEM, overall symptoms getting worse after mild activity). In addition, cognitive issues, orthostatic intolerance (dizziness or nausea when upright) or other physical symptoms may be present (see also § Diagnostic criteria ).
The initial chronic fatigue syndrome definition was published in 1988. It is also called the "Holmes definition", after the manuscript's first author. [10] The Homes criteria require these two points: Debilitating fatigue of new onset which interferes with the patient's daily activities; Other fatiguing conditions must be eliminated
Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) [1] or post-exertional neuroimmune exhaustion (PENE), [2] is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID and ...
Few things feel quite as debilitating or frustrating as fatigue. ... “Fatigue is an extremely common symptom seen in general practice,” says Dr Angela Rai, GP at the Harley Street GP clinic ...
Also, unlike fatigue from overtraining, you’re likely to have additional symptoms specific to your health concern, such as nausea, joint pain, and shortness of breath.
Some clinicians, however, fail to differentiate between side effects and root causes, or use screening techniques that aren’t well suited for people with chronic conditions, Verduzco-Gutierrez says.