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Fibrodysplasia ossificans progressiva (/ ˌ f aɪ b r oʊ d ɪ ˈ s p l eɪ ʒ (i) ə ɒ ˈ s ɪ f ɪ k æ n z p r ə ˈ ɡ r ɛ s ɪ v ə /; [1] abbr. FOP), also called Münchmeyer disease or formerly myositis ossificans progressiva, is an extremely rare connective tissue disease in which fibrous connective tissue such as muscle, tendons, and ligaments turn into bone tissue (ossification).
Distal expansion of the long bones as well as painful, swollen joints [3] and synovial villous proliferation are often seen. The condition may occur alone (primary), or it may be secondary to diseases like lung cancer.
In traumatic heterotopic ossification (traumatic myositis ossificans), the patient may complain of a warm, tender, firm swelling in a muscle and decreased range of motion in the joint served by the muscle involved. There is often a history of a blow or other trauma to the area a few weeks to a few months earlier.
Even a small bleed or muscle swelling can greatly raise the pressure. [8] [6] [5] The pathophysiology of CECS is not entirely understood. In CECS, pressure in an anatomical compartment increases due to a 20% increase in muscle volume. [42] This builds pressure in the tissues and muscles, causing ischemia. [42]
Swelling can also signal something more serious; some people with psoriasis get psoriatic arthritis, which can cause finger swelling; people who have had lymph nodes removed can also have a ...
Eventually, subperiosteal bone formation may give a firm swelling. Trismus (difficulty opening the mouth), which may be present in some cases and is caused by edema in the muscles. Dysphagia (difficulty swallowing), which may be present in some cases and is caused by edema in the muscles. Cervical lymphadenitis (swelling of the lymph nodes in ...
Musculoskeletal injuries can affect any part of the human body including; bones, joints, cartilages, ligaments, tendons, muscles, and other soft tissues. [1] Symptoms include mild to severe aches, low back pain, numbness, tingling, atrophy and weakness.
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