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VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family.
Hypothetic models of VAMP2 conformations and engagement in SNARE complex assembly for neurotransmitter release. Vesicle associated membrane proteins (VAMPs) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.
VAP stands for VAMP-associated protein, [2] where VAMP stands for vesicle-associated membrane protein. Humans have two VAPs that consist of the essential Major Sperm Protein domain and linker plus transmembrane helix to attach to the ER: VAPA and VAPB . [ 3 ]
VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion . Mice lacking functional synaptobrevin2/VAMP2 gene cannot survive after birth, and have a dramatically reduced synaptic transmission, around 10% of control. [ 7 ]
Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene. [5] [6] [7]Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane.
Marlee Matlin has counted Henry Winkler as a close friend for decades, as a new documentary about the Oscar-winning actress attests.. In director Shoshannah Stern’s new project, Marlee Matlin ...
Marceline is a half-demon and half-human vampire. [19] She assumed the title "Vampire Queen" after having killed the previous Vampire King prior to the start of the show. [29] [35] Although she is over 1,000 years old, she takes on the physical appearance of an 18- to 21-year-old. [74]