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54206 74155 Ensembl ENSG00000116285 ENSMUSG00000028967 UniProt Q9UJM3 Q99JZ7 RefSeq (mRNA) NM_018948 NM_133753 NM_001356323 RefSeq (protein) NP_061821 NP_598514 NP_001343252 Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.94 – 150.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is ...
Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression". The manner by which this happens is dependent on the control mechanisms as well as differences between prokaryotic and eukaryotic cells.
DDIT4 acts as a negative regulator of mTOR, [7] a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. [8] In particular, upregulation of HIF-1 in response to hypoxia upregulates DDIT4, [5] leading to activation of Tsc1/2 via 14–3–3 shuttling [9] and subsequent downregulation of mTOR via Rheb. [10]
Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme. Enzyme inhibition can refer to the inhibition of the expression of the enzyme by another molecule; interference at the enzyme-level, basically with how the enzyme works.
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
10912 23882 Ensembl ENSG00000130222 ENSMUSG00000021453 UniProt O95257 Q9Z111 Q9R0S0 RefSeq (mRNA) NM_006705 NM_011817 RefSeq (protein) NP_006696 NP_035947 Location (UCSC) Chr 9: 89.61 – 89.61 Mb Chr 13: 52 – 52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on ...
p21 Cip1 (alternatively p21 Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, [5] though is primarily associated with inhibition of CDK2.
Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts. Lack of activin during development results in neural developmental defects.