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Progressive supranuclear palsy (PSP) is a late-onset neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain. [1] [2] The condition leads to symptoms including loss of balance, slowing of movement, difficulty moving the eyes, and cognitive impairment. [1]
PSP has been all over the news—here's what to know about it.
Additional features include bradykinesia, early-onset postural instability, increased rigidity in axial muscles, dysautonomia, alien limb syndrome, supranuclear gaze palsy, apraxia, involvement of the cerebellum including the pyramidal cells, and in some instances significant cognitive impairment.
Progressive supranuclear palsy (PSP) is a type of tauopathy, but the cause is not yet discovered. For PSP unusual phosphorylation for tau protein causes vital protein filaments in the nerve cells to destruct, a phenomenon called "neurofibrillary" degeneration.
Paralysis of upwards gaze: Downward gaze is usually preserved. This vertical palsy is supranuclear, so doll's head maneuver should elevate the eyes, but eventually all upward gaze mechanisms fail. In the extreme form, conjugate down gaze in the primary position, or the "setting-sun sign" is observed.
Cerebral palsy, a neural disorder caused by intracranial lesions; Conjugate gaze palsy, a disorder affecting the ability to move the eyes; Erb's palsy, also known as brachial palsy, involving paralysis of an arm; Spinal muscular atrophy, also known as wasting palsy; Progressive supranuclear palsy, a degenerative disease
These symptoms that aid in clinical diagnosis are collectively referred to as corticobasal syndrome (CBS) or corticobasal degeneration syndrome (CBDS). Alzheimer's disease, Pick's disease, FTDP-17 and progressive supranuclear palsy can display a corticobasal syndrome.
progressive supranuclear palsy, Parkinson's disease The procerus sign ( vertical wrinkling of the forehead ) is a medical sign consisting of vertical forehead wrinkling around the bridge of the nose and the glabella .