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Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; [2] it is a type of viral hepatitis. [6] During the initial infection period, people often have mild or no symptoms. [1] Early symptoms can include fever, dark urine, abdominal pain, and yellow tinged skin. [1]
The hepatitis C virus (HCV) [3] is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatocellular carcinoma , abbreviated HCC) and lymphomas in humans.
The frequent association of anti-LKM-1 antibodies and hepatitis C virus (HCV) infections and the probable existence of an infection-associated autoimmune form of anti-LKM-1-associated hepatitis, requiring a different therapeutic strategy, necessitate the exact determination of anti-LKM-1 specificities. [3] [5] [6]
In the 1970s and 1980s, blood transfusions were a major factor in spreading hepatitis C virus. [32] Since widespread screening of blood products for hepatitis C began in 1992, the risk of acquiring hepatitis C from a blood transfusion has decreased from approximately 10% in the 1970s to 1 in 2 million currently. [17]
An anti-LKM antibody (anti–liver-kidney microsomal antibody or LKM antibody) is any of several autoantibodies that are detected in the serum of patients with different types of acute or chronic liver disease. These antibodies are targeted against antigens of the cytochrome P450 system.
human anti-chimeric antibody: HACE: High-altitude cerebral edema: HACEK: acronym for a group of bacteria that are a frequent cause of endocarditis in children HAD: HIV-associated dementia: HADS: Hospital Anxiety and Depression Scale: HAE: hereditary angioedema: H/A: headache: HAI: healthcare-associated infection or hospital-acquired infection: HALE