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Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. [5] [6] [10] Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.
Endometrial biopsy in those with high risk endometrial cancer or atypical hyperplasia or malignancy. [16] Sonohysterography to assess for abnormalities within the uterine lining [17] Hysteroscopy (anaesthesia should be offered) [16] Thyroid-stimulating hormone and thyrotropin-releasing hormone dosage to rule out hypothyroidism [18]
Endometriosis can also impact a woman's fetus or neonate, increasing the risks for congenital malformations, preterm delivery and higher neonatal death rates. [46] Endometriosis can lead to ovarian cysts (endometriomas), adhesions, and damage to the fallopian tubes or ovaries, all of which can interfere with ovulation and fertilization.
Uterine cancer, also known as womb cancer, includes two types of cancer that develop from the tissues of the uterus. [3] Endometrial cancer forms from the lining of the uterus, and uterine sarcoma forms from the muscles or support tissue of the uterus. [1] [2] Endometrial cancer accounts for approximately 90% of all uterine cancers in the ...
The most frequent type of endometrial cancer is endometrioid carcinoma, which accounts for more than 80% of cases. [3] Endometrial cancer is commonly diagnosed by endometrial biopsy or by taking samples during a procedure known as dilation and curettage. [1] A pap smear is not typically sufficient to show endometrial cancer. [4]
Gynecologic cancer is a type of cancer that affects the female reproductive system, including ovarian cancer, uterine cancer, vaginal cancer, cervical cancer, and vulvar cancer. Gynecological cancers comprise 10-15% of women's cancers, mainly affecting women past reproductive age but posing threats to fertility for younger patients. [ 1 ]
In patients with suspected uterine cancer, the biopsy may discover the presence of cancer cells in the endometrium or cervix. In female infertility the assessment of the lining can determine, if properly timed, that the patient ovulated, however, the same information can be obtained by a blood test of the progesterone level.
There is an association with endometriosis and concurrent primary endometrial carcinoma (endometrial cancer). On gross pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40% of cases, endometrioid tumors are found bilaterally.
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