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At just $19 (down from $33), this serum is a fraction of the price of many high-end skin-care products with retinol, which can run you upward of $50 or even $100. RoC has been a respected brand ...
Shoppers say the RoC formula gave them visibly plumper, more hydrated skin — it's worth a try at half-off. Reviewers in their 70s say this anti-aging serum makes a difference — now it's 50% ...
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Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. [8] [9] [10] For acne, it is applied to the skin as a cream, gel or ointment. [10]
First generation retinoids are produced naturally in the body and interact with their normal biological counterparts, such as retinol binding protein 4 for retinol, retinoid receptors for all-trans-retinoic acid or 9-cis-retinoic acid. [9] 13-cis retinoic acid has an unknown biological pathway but appears to act as a growth factor. [10]
Retinol is reversibly converted to retinal, then irreversibly to retinoic acid, which activates hundreds of genes. [9] Vitamin A deficiency is common in developing countries, especially in Sub-Saharan Africa and Southeast Asia. Deficiency can occur at any age but is most common in pre-school age children and pregnant women, the latter due to a ...