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A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. Given a sample of DNA, a DNA sequencer is used to determine the order of the four bases: G (), C (), A and T ().
In June 2009, Illumina announced that they were launching their own Personal Full Genome Sequencing Service at a depth of 30× for $48,000 per genome. [ 60 ] [ 61 ] In August, the founder of Helicos Biosciences, Stephen Quake , stated that using the company's Single Molecule Sequencer he sequenced his own full genome for less than $50,000. [ 62 ]
PacBio/Oxford Nanopore reads [16] 2016 / 2018 OS link: MaSuRCA Any size, haploid/diploid genomes Illumina and PacBio/Oxford Nanopore data, legacy 454 and Sanger data [17] 2011 / 2018 OS link: Newbler: genomes, ESTs 454, Sanger 454 Life Sciences: 2004/2012 C link: Phrap: genomes Sanger, 454, Solexa Green, P. 1994 / 2008 C / NC-A link: Plass ...
The company's first scientific instrument, called the PacBio RS, was released to a limited set of customers in late 2010., with full commercial release in early 2011. [17] [8] Sequencing provider GATC Biotech was selected by Pacific Biosciences as its first European service provider in late 2010. [18]
Sequencing technologies with a different approach than second-generation platforms were first described as "third-generation" in 2008–2009. [4]There are several companies currently at the heart of third generation sequencing technology development, namely, Pacific Biosciences, Oxford Nanopore Technology, Quantapore (CA-USA), and Stratos (WA-USA).
In November 2018, Illumina proposed the acquisition of Pacific Biosciences for $8.00 per share or around $1.2 billion in total. [30] [31] In December 2019, the Federal Trade Commission (FTC) sued to block the acquisition. [32] The proposed deal was abandoned on January 2, 2020, with Illumina paying Pacific a $98 million termination fee. [33]
Public health laboratories (PHL) and other laboratories around the world have played a pivotal role in providing rapid sequencing data for the surveillance of the virus SARS-CoV-2, causative agent for COVID-19, during the pandemic that was declared a public health emergency on January 30, 2020. [10]