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Cryoprecipitate, also called cryo for short, or Cryoprecipitate Antihemophilic factor (AHF), is a frozen blood product prepared from blood plasma. [1] To create cryoprecipitate, Plasma is slowly thawed to 1–6 °C. A cold-insoluble precipitate is formed, which is collected by centrifugation, resuspended in a small amount of residual plasma ...
Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood. [3] It is used to treat conditions in which there are low blood clotting factors (INR > 1.5) or low levels of other blood proteins. [3] [1] It may also be used as the replacement fluid in plasma exchange.
The term cryosupernatant (also called cryo-poor plasma, cryoprecipitate depleted, cryoprecipitate reduced plasma) refers to plasma from which the cryoprecipitate has been removed. It is used to treat thrombocytopenic purpura .
The time required for transportation and processing often precludes production of FFP in such cases; that is the plasma cannot be separated and frozen within 8 hours of collection. However, the (male) donor blood can be separated into packed red blood cells and plasma within 24 hours (and usually less). [citation needed]
A blood product is any therapeutic substance prepared from human blood. [1] This includes whole blood; blood components; and plasma derivatives.Blood components include: red blood cell concentrates or suspensions; platelets produced from whole blood or via apheresis; Granulocyte, plasma; and cryoprecipitate.
[2] [3] Other measures may include giving platelets, cryoprecipitate, or fresh frozen plasma. [2] Evidence to support these treatments, however, is poor. [2] Heparin may be useful in the slowly developing form. [2] About 1% of people admitted to hospital are affected by the condition. [4] In those with sepsis, rates are between 20% and 50%. [4]
Packed red blood cells, fresh frozen plasma, and platelets are generally administered. [131] Typical ratios of fresh frozen plasma, platelets and packed red blood cells are between 1:1:1 and 1:1:2. [132] In some locations, blood has begun to be administered pre-hospital in an effort to reduce preventable deaths from significant blood loss.
Most blood banks now split the whole blood into two or more components, [18] typically red blood cells and a plasma component such as fresh frozen plasma. Platelets for transfusion can also be prepared from a unit of whole blood, whereby 4 or 5 buffy coats are pooled to produce a platelet component.