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Paracellular transport refers to the transfer of substances across an epithelium by passing through the intercellular space between the cells. [1] It is in contrast to transcellular transport , where the substances travel through the cell, passing through both the apical membrane and basolateral membrane .
In contrast, paracellular transport is the transfer of substances across an epithelium by passing through an intercellular space between the cells. It differs from transcellular transport, where the substances travel through the cell passing through both the apical membrane and basolateral membrane; Renal physiology. Transcellular transport is ...
Molecules are transported across an epithelial or endothelial barrier by one of two routes: 1) a transcellular route through the intracellular compartment of the cell, or 2) a paracellular route through the extracellular space between adjacent cells. [18] The transcellular route is also called transcytosis.
The transcellular (through the cells) and paracellular (between the cells) routes control the passage of substances between the intestinal lumen and blood. The barrier formed by the intestinal epithelium separates the external environment (the contents of the intestinal lumen ) from the body [ 6 ] and is the most extensive and important mucosal ...
The transcellular fluid is the portion of total body fluid that is formed by the secretory activity of epithelial cells and is contained within specialized epithelial-lined compartments. Fluid does not normally collect in larger amounts in these spaces, [ 6 ] [ 7 ] and any significant fluid collection in these spaces is physiologically ...
Scheme of selective permeability routes of epithelial cells (red arrows). The transcellular (through the cells) and paracellular (between the cells) routes control the passage of substances between the intestinal lumen and blood. This consists of specific transport of solutes across the epithelial cells. It is predominantly regulated by the ...
When the topical drug molecules transport via the paracellular route, it needs to travel across the stratum corneum, which is a highly fat region, but between the cells. [9] [1] On the other hand, the topical drug molecules may travel through the transcellular route. This route allows molecules to be transported via the cell.
Two routes of Ca 2+ absorption are recognized: paracellular transport and transcellular transport (see Figure 4). [55] A high-Ca 2+-diet favors paracellular transport of the ion across the length of the intestine allowing them to pass between the intercellular tight junctions that connect epithelial cells.