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Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called Salmonella Typhi. [2] [3] Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. [4] [5] Often there is a gradual onset of a high fever over several days. [4]
The CDC recommendation is either a single oral dose (1 gram) of azithromycin, a single IM dose (250 mg) of ceftriaxone, oral (500 mg) of erythromycin three times a day for seven days, or oral (500 mg) of ciprofloxacin twice a day for three days. No Varicella zoster virus (VZV) Chickenpox
Typhoid vaccines are vaccines that prevent typhoid fever. [1] [2] [3] Several types are widely available: typhoid conjugate vaccine (TCV), Ty21a (a live oral vaccine) and Vi capsular polysaccharide vaccine (ViPS) (an injectable subunit vaccine). They are about 30 to 70% effective in the first two years, depending on the specific vaccine in ...
Ty21a is a live attenuated bacterial vaccine that protects against typhoid.First licensed in Europe in 1983 and in the United States in 1989, it is an orally administered, live-attenuated Ty2 strain of S. Typhi in which multiple genes, including the genes responsible for the production of Vi, have been deleted so as to render it harmless but nevertheless immunogenic.
Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of several bacterial infections. [10] This includes middle ear infections , strep throat , pneumonia , traveler's diarrhea , and certain other intestinal infections . [ 10 ]
Typhoid fever is caused by the bacterium Salmonella enterica Serovar Typhi. [ 37 ] In Canada alone, the typhus epidemic of 1847 killed more than 20,000 people from 1847 to 1848, mainly Irish immigrants in fever sheds and other forms of quarantine, who had contracted the disease aboard the crowded coffin ships in fleeing the Great Irish Famine .
Since November 2016, Pakistan has had an outbreak of extensively drug-resistant (XDR) typhoid fever. [ 43 ] In 2020 a meta-analysis of reports of drug resistant typhoid fever revealed that among all Typhi isolates, 9,056 (25.9%) of 34,996 were resistant to chloramphenicol, 13,481 (38.8%) of 34,783 to ampicillin, and 13,366 (37.9%) of 35,270 to ...
The discovery that oral antibiotic azithromycin can be used instead of the previous standard, injected penicillin, was tested on Lihir Island from 2013 to 2014; [58] a single oral dose of the macrolide antibiotic reduced disease prevalence from 2.4% to 0.3% at 12 months. [59]
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