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An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Valproic acid has a black box warning for hepatotoxicity, pancreatitis, and fetal abnormalities. [4] There is evidence that valproic acid may cause premature growth plate ossification in children and adolescents, resulting in decreased height. [36] [37] [38] Valproic acid can also cause mydriasis, a dilation of the pupils. [39]
This page was last edited on 4 November 2024, at 20:46 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Examples include valproic acid, [2] vigabatrin, [3] [4] phenylethylidenehydrazine (and drugs that metabolize to it, such as phenelzine [5]), ethanolamine-O-sulfate (EOS), and L-cycloserine. [ 6 ] Certain members of this class are used as anticonvulsants .
The term injection encompasses intravenous (IV), intramuscular (IM), subcutaneous (SC) and intradermal (ID) administration. [35] Parenteral administration generally acts more rapidly than topical or enteral administration, with onset of action often occurring in 15–30 seconds for IV, 10–20 minutes for IM and 15–30 minutes for SC. [36]
Minor limb malformations seen after valproate exposure. Fetal valproate spectrum disorder (FVSD), previously known as fetal valproate syndrome (FVS), is a rare disease caused by prenatal exposure to valproic acid (VPA), a medication commonly used to treat epilepsy, bipolar disorder, and migraines.
Pharmacokinetics: . Process of the uptake of drugs by the body, the biotransformation they undergo, the distribution of the drugs and their metabolites in the tissues, and the elimination of the drugs and their metabolites from the body over a period of time.
Valpromide is no safer during pregnancy than valproic acid. Valpromide is formed through the reaction of valproic acid and ammonia via an intermediate acid chloride. In pure form, valpromide is a white crystalline powder and has a melting point 125–126 °C. It is soluble only in hot water. It is available on the market in some European countries.
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