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Histamine N-methyltransferase is encoded by a single gene, called HNMT, which has been mapped to chromosome 2 in humans. [5]Three transcript variants have been identified for this gene in humans, which produce different protein isoforms [6] [5] due to alternative splicing, which allows a single gene to code for multiple proteins by including or excluding particular exons of a gene in the final ...
Important examples of this enzyme class in humans include phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, [14] and histamine N-methyltransferase (HNMT), which methylates histamine in the process of histamine metabolism. [15]
In the central nervous system, histamine released into the synapses is primarily broken down by histamine-N-methyltransferase, while in other tissues both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2 , further process the immediate metabolites of histamine for excretion or recycling.
SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels. [1] [2] See also
In enzymology, a protein-histidine N-methyltransferase (EC 2.1.1.85) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + protein L-histidine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine
N-methyltransferase may refer to: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase; ... Histamine N-methyltransferase; Histone methyltransferase
NMH is formed by N τ-methylation of histamine, catalyzed by the enzyme Histamine N-methyltransferase. NMH is excreted in the urine and can be measured as a biomarker of histamine activity. [2] While NMH has some biological activity on its own, it is much weaker than histamine.
The genes encoding carnosine N-methyltransferase activity have been identified by Jakub Drozak and coworkers in 2013 [1] and 2015. [2] In birds and reptiles, the enzyme is encoded by histamine N-methyltransferase-like gene (HNMT-like). [1]