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When a muscle is stretched, primary type Ia sensory fibers of the muscle spindle respond to both changes in muscle length and velocity and transmit this activity to the spinal cord in the form of changes in the rate of action potentials. Likewise, secondary type II sensory fibers respond to muscle length changes (but with a smaller velocity ...
The compound muscle action potential (CMAP) is the resulting response and depends on the motor axons transmitting the action potential, the status of the neuromuscular junction, and muscle fibers. The CMAP amplitudes, motor onset latencies, and conduction velocities are routinely assessed and analyzed.
Many nuclei are needed by the skeletal muscle cell for the large amounts of proteins and enzymes needed to be produced for the cell's normal functioning. A single muscle fiber can contain from hundreds to thousands of nuclei. [25] A muscle fiber for example in the human biceps with a length of 10 cm can have as many as 3,000 nuclei. [25]
In single-fiber electromyography, which is considered to be the most sensitive (although not the most specific) test for MG, [20] a thin needle electrode is inserted into different areas of a particular muscle to record the action potentials from several samplings of different individual muscle fibers. Two muscle fibers belonging to the same ...
A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. [1] It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. [2] Muscles require innervation to function—and even just to maintain muscle tone, avoiding atrophy.
Single fiber electromyography assesses the delay between the contractions of individual muscle fibers within a motor unit and is a sensitive test for dysfunction of the neuromuscular junction caused by drugs, poisons, or diseases such as myasthenia gravis.
[12] [14] However, before subjecting a patient to nerve conduction studies, both Tinel's test and Phalen's test should be performed. If both results are negative, it is very unlikely that the patient has CTS, and further testing is unnecessary. [13] Carpal tunnel syndrome presents in each individual to different extents.
Intrafusal muscle fibers are skeletal muscle fibers that serve as specialized sensory organs (proprioceptors). [ 1 ] [ 2 ] They detect the amount and rate of change in length of a muscle . [ 1 ] They constitute the muscle spindle , [ 2 ] and are innervated by both sensory (afferent) and motor (efferent) fibers.