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Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. There are four categories of cerebral hypoxia; they are, in order of increasing severity: diffuse cerebral hypoxia (DCH), focal cerebral ischemia , cerebral infarction ...
Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury. [34] [35] Oxygen deprivation can be hypoxic (reduced general oxygen availability) or ischemic (oxygen deprivation due to a disruption in blood flow) in origin. Brain injury as a result of oxygen deprivation is generally termed hypoxic injury.
Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. [10] Multiple cerebral ischemic events may lead to subcortical ischemic depression, also known as vascular depression. This condition is most commonly seen in elderly depressed patients.
Other common causes of chronic organic brain syndrome sometimes listed are the various types of dementia, which result from permanent brain damage due to strokes, [7] Alzheimer's disease, or other damaging causes which are irreversible. Amnestic pertains to amnesia and is the impairment in ability to learn or recall new information, or recall ...
In more severe instances, global hypoxia-ischemia causes widespread brain injury leading to a severe cognitive sequelae called hypoxic-ischemic encephalopathy. [ 37 ] An ischemic cascade occurs where an energetic molecular problem arises due to lack of oxygen and nutrients.
A subdural hygroma (SDG) is a collection of cerebrospinal fluid (CSF), without blood, located under the dural membrane of the brain. Most subdural hygromas are believed to be derived from chronic subdural hematomas. They are commonly seen in elderly people after minor trauma but can also be seen in children following infection or trauma.
The human brain shows a decline in function and a change in gene expression. This modulation in gene expression may be due to oxidative DNA damage at promoter regions in the genome. [28] Genes that are down-regulated over the age of 40 include: [citation needed] GluR1 AMPA receptor subunit; NMDA R2A receptor subunit (involved in learning)
Symptoms of chronic subdural hematomas are usually delayed more than three weeks after injury. [1] If the bleeds are large enough to put pressure on the brain, signs of increased intracranial pressure or brain damage will be present. [3] Other symptoms of subdural hematoma can include any combination of the following: [7]