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The mucosa lining the cervical canal is known as the endocervix, [5] and the mucosa covering the ectocervix is known as the exocervix. [6] The cervix has an inner mucosal layer, a thick layer of smooth muscle, and posteriorly the supravaginal portion has a serosal covering consisting of connective tissue and overlying peritoneum. [4]
The cervical canal is generally lined by "endocervical mucosa" which consists of a single layer of mucinous columnar epithelium. However, after menopause, the functional squamocolumnar junction moves into the cervical canal, and hence the distal part of the cervical canal may be lined by stratified squamous epithelium (conforming to a "type 3 transformation zone").
In addition to differences in nearly every reproductive organ, there are numerous differences in typical secondary sex characteristics. Human reproduction usually involves internal fertilization by sexual intercourse. In this process, the male inserts his penis into the female's vagina and ejaculates semen, which contains sperm.
CIN most commonly occurs at the squamocolumnar junction of the cervix, a transitional area between the squamous epithelium of the vagina and the columnar epithelium of the endocervix. [2] It can also occur in vaginal walls and vulvar epithelium. CIN is graded on a 1–3 scale, with 3 being the most abnormal (see classification section below).
Sexual differentiation is the process of development of the sex differences between males and females from an undifferentiated zygote. [1] [2] Sex determination is often distinct from sex differentiation; sex determination is the designation for the development stage towards either male or female, while sex differentiation is the pathway towards the development of the phenotype.
XY differences of sex development – Atypical androgen production or inadequate androgen response, which can cause incomplete masculinization in XY males. Varies from mild failure of masculinization with undescended testes to complete sex reversal and female phenotype (Androgen insensitivity syndrome) Swyer syndrome.
The vaginal epithelium is the inner lining of the vagina consisting of multiple layers of cells. [1] [2] [3] The basal membrane provides the support for the first layer of the epithelium-the basal layer.
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