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Gout most often affects middle-aged and older men. In fact, men are three to 10 times more likely to have gout than women. However, younger men and women of all ages can have gout.
Gout is a form of inflammatory arthritis characterized by recurrent attacks of a single red, tender, hot, and swollen joint. [ 1 ] [ 2 ] Pain typically comes on rapidly, reaching maximal intensity in less than twelve hours. [ 3 ]
Gout was historically known as "the disease of kings" or "rich man's disease" [3] [8] and has been recognized since at least the time of the ancient Egyptians. [ 3 ] References
If you have frequent gout flares, gout associated with tophi, or joint damage, your provider may prescribe medication to lower uric acid levels. These can help prevent gout flares and further ...
Gout presenting as slight redness in the metatarsophalangeal joint of the big toe. Gout can present in several ways, although the most common is a recurrent attack of acute inflammatory arthritis (a red, tender, hot, swollen joint). [4] The metatarsophalangeal joint at the base of the big toe is affected most often, accounting for half of cases ...
Gout can occur where serum uric acid levels are as low as 6 mg per 100 mL (357 μmol/L), but an individual can have serum values as high as 9.6 mg per 100 mL (565 μmol/L) and not have gout. [ 18 ] In humans, purines are metabolized into uric acid, which is then excreted in the urine.
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [4] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Without treatment, tophi may develop on average about ten years after the onset of gout, although their first appearance can range from three to forty-two years. The development of gouty tophi can also limit joint function and cause bone destruction, leading to noticeable disabilities, especially when gout cannot successfully be treated. [ 2 ]