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The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
Atrophy of the hippocampus has been observed during depression, consistent with animal models of stress and neurogenesis. [116] [117] Stress can cause depression and depression-like symptoms through monoaminergic changes in several key brain regions as well as suppression in hippocampal neurogenesis. [118]
Cerebral atrophy is a common feature of many of the diseases that affect the brain. [1] Atrophy of any tissue means a decrement in the size of the cell, which can be due to progressive loss of cytoplasmic proteins. In brain tissue, atrophy describes a loss of neurons and the connections between them.
“Depression is a lot of different things with a lot of different causes, biological changes and treatments,” said Dr. Richard Keefe, professor emeritus of psychiatry and behavioral sciences at ...
In contrast to major depression, dementia is a progressive neurodegenerative syndrome involving a pervasive impairment of higher cortical functions resulting from widespread brain pathology. [ 7 ] A significant overlap in cognitive and neuropsychological dysfunction in dementia and pseudodementia patients increases the difficulty in diagnosis.
Psychoorganic syndrome is a combination of various symptoms that are caused by organic changes in the brain. [5] The exact component of the solvents that causes the neurological disorder is difficult to isolate due to worker generally being exposed to mixtures of various grades, compositions, and purity of solvents. [6]
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