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Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat partial seizures and neuropathic pain. [ 7 ][ 10 ] It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [ 11 ]
Gabapentin has been prescribed off-label for anxiety despite a lack of research evidence supporting such use, although some studies have indicated that it may relieve anxiety symptoms. The potential anxiolytic effect of tiagabine has been observed in some pre-clinical trials, but its effectiveness has not yet been proved.
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
Several drugs used to treat epilepsy, including gabapentin, may cause dysfunction in men. Gabapentin could cause ED, desire changes and dysfunction. There’s evidence that gabapentin may affect a ...
Generalized anxiety disorder (GAD) is a mental and behavioral disorder, [5] specifically an anxiety disorder characterized by excessive, uncontrollable and often irrational worry about events or activities. [6] Worry often interferes with daily functioning, and individuals with GAD are often overly concerned about everyday matters such as ...
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma -aminobutyric acid. The two receptors GABA-α and GABA-ρ are ion channels ...